Israeli scientists unlock genetic links to Autism, brain disorder using CRISPR tech -study

[angryxyouth]

Source: Jerusalem Post

The study used large-scale CRISPR gene-editing technology to systematically determine which genes are required as embryonic stem cells develop into brain

ByPESACH BENSON/TPS, OMER NOVOSELSKY/TPS
JANUARY 7, 2026 20:41


An international team of scientists has identified hundreds of genes that are essential for early brain development, uncovering new insights into the biological roots of neurodevelopmental disorders, including autism, and describing a previously unknown genetic condition that disrupts brain growth, the Hebrew University of Jerusalem announced.

The study, published in the peer-reviewed journal Nature Neuroscience, used large-scale CRISPR gene-editing technology to systematically determine which genes are required as embryonic stem cells developed into brain cells.


Read more: https://www.jpost.com/health-and-wellness/article-882674

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It looks like vaccines have nothing to do with autism.

[dweller]

1. Will we ever learn what the

“ unknown genetic condition that disrupts brain growth”
is ?



✌🏻

[SunSeeker]

3. Gene mutations in the sperm of older men.

Extensive research shows a significant link between older paternal age (especially over 40-50) and an increased risk of Autism Spectrum Disorder (ASD) in children, with some studies finding children of older fathers are several times more likely to be diagnosed compared to those with younger fathers, often linked to accumulated genetic mutations in sperm. While maternal age also plays a role, paternal age shows a stronger correlation, and mechanisms include new gene mutations and epigenetic changes, though other factors may also contribute. https://pmc.ncbi.nlm.nih.gov/articles/PMC7396152/#:~:text=A%20recent%20meta%2Danalysis%20examining,may%20relate%20to%20these%20mechanisms.

[littlemissmartypants]

8. From the study you cited:

Discussion
...
We did not observe significant associations with increasing ASD-related outcomes and advanced parental age here.

Snip...

Instead, we observed stronger associations, which reached statistical significance in analyses of ASD diagnosis, with younger paternal age.
...

https://pmc.ncbi.nlm.nih.gov/articles/PMC7396152/#:~:text=A%20recent%20meta%2Danalysis%20examining,may%20relate%20to%20these%20mechanisms.

[SunSeeker]

9. Correct, it's not parental age, but paternal age. The Abstract clearly states the significance of paternal age.

Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14–7.02).

So yeah, it's not so much the age of the mother and father combined ("parental age" ) as it is the father's advanced age ("paternal age" ) that correlates with a several fold increase in the risk of autism.

That is probably because there's lots of men over 40 fathering babies. Look at Mick Jagger, now 82. He had his 8th child with his 5th wife in 2016. He was 73, she was 29 in 2016. Women over 40 are much less likely to be producing babies. So when you're talking about old people having babies, you're talking about men.

[littlemissmartypants]

11. Less than 30 years old does not qualify as advanced age last time I checked.

I think you should look at the results you quoted again.

[SunSeeker]

12. That is referring to the "U shaped" increase in ASD with very young fathers and old fathers (over 40).

It goes on to state:

Two studies conducted within populations of twins have reported U-shaped relationships with paternal age and ASD or social-emotional development measured by the Strengths and Difficulties Questionnaire [Janecka, Haworth, et al., 2017; Lundstrom et

https://pmc.ncbi.nlm.nih.gov/articles/PMC7396152/#:~:text=A%20recent%20meta%2Danalysis%20examining,may%20relate%20to%20these%20mechanisms.

But the increase in ASD risk among very young fathers is not nearly as high as with old fathers, and it's the over 40 population of the "U" that is increasing in number and has the much more significant risk.

Here is conclusion of another, more recent article, from the ABA:

A notable finding is that the risk of autism in children rises steadily with paternal age. For example, men in their 30s are 1.6 times more likely to have a child with autism than men under 30. This risk increases further with age—fathers in their 40s have a sixfold increase, and those over 55 are four times more likely.

https://doublecareaba.com/post/do-older-fathers-cause-autism#:~:text=Studies%20across%20multiple%20species%2C%20including,neurodevelopmental%20disorders%20such%20as%20autism.

And here's an article in JAMA:

There was a significant monotonic association between advancing paternal age and risk of ASD. Offspring of men 40 years or older were 5.75 times (95% confidence interval, 2.65-12.46; P < .001) more likely to have ASD compared with offspring of men younger than 30 years, after controlling for year of birth, socioeconomic status, and maternal age. Advancing maternal age showed no association with ASD after adjusting for paternal age. Sensitivity analyses indicated that these findings were not the result of bias due to missing data on maternal age.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/668208#

[littlemissmartypants]

14. I read the study and I don't believe it proves what you think it proves.

I don't know why you keep posting these long paragraphs. I disagree with your assumptions. It's just that simple. So, that's the end of it as far as I'm concerned. But thanks for the replies. ❤️ 👋

[Deep State Witch]

13. We Think That's Why My Husband Is Autistic

My husband is on the Spectrum. He's been misdiagnosed since he was a toddler. In fact, it's only been in the last few years that he's figured it out and claimed the label of AuDHD. (Autistic + ADHD) Now, he doesn't want to be labeled as autistic because of RFK. His father was about 20 years older than his mother. His father may have been on the Spectrum as well. We don't have children, but his niece from his younger brother is on the Spectrum - even though both of her parents are close in age.

[SunSeeker]

2. An NIH study found that children with autism are less likely to be fully vaccinated.

https://www.ncbi.nlm.nih.gov/search/research-news/3538/


So if anything, vaccines protect kids from autism.

[rampartd]

4. i wouldn't go that far. they don't put the mercury stuff in vaccines anymore

the israelis have evidence that this is genetic, but it might be that some children have more interaction with nurturing adults and therefore learn greater social skills?

[SunSeeker]

5. Stop it! Mercury (Thimerosal) in vaccines does NOT cause autism.

Numerous large-scale scientific studies and major medical organizations worldwide have definitively concluded that mercury in vaccines does not cause autism. The scientific consensus is that there is no causal link between the two. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/thimerosal-and-vaccines#:~:text=back%20to%20top-,No%20Link%20between%20Thimerosal%20in%20Vaccines%20and%20Autism,at%20the%20site%20of%20injection.

Thimerosal was removed from vaccines (thanks to unfounded fear mongering) 20 YEARS AGO, yet autism diagnoses have only increased. But you know what else has sharply increased over the last 20 years? Old men fathering babies. And THAT is directly associated with a several fold increase in autism risk.

[rampartd]

6. i don't think it ever did

if thimerosal was removed 20 years ago and we still get autistic kids , that's good evidence that autism might be caused by something else.

[LudwigPastorius]

7. A slightly more informative article on the same subject:

https://www.genengnews.com/topics/omics/crispr-screen-uncovers-genes-driving-brain-cell-development-neurodevelopmental-disorder/

[OverBurn]

10. So it's not the Tylenol?